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目的观察加替沙星日单次给药治疗呼吸及泌尿系细菌感染的临床疗效,并与相同日剂量分2次给药进行疗效对照,从药效学角度探索加替沙星治疗细菌性感染合理给药方案。方法将142例细菌性感染患者随机分A、B2组,A组采用加替沙星0.4g溶于0.9%氯化钠注射液200ml中缓慢静滴,qd,3天后改为口服0.4g,qd;B组采用加替沙星0.2g溶于0.9%氯化钠注射液100ml中缓慢静滴,bid,3天后改为口服0.2g,bid,2组疗程均为7-10d,观察治疗结束时临床有效率、细菌清除率,及各患者用药过程中出现的各种用药不良反应,并比较2组患者实际用药天数。结果A、B组临床有效率分别为93.59%、87.5%(P<0.05),细菌清除率分别为95.59%、87.27%(P<0.05),2组患者实际用药天数分别为7.2±0.9、9.1±1.7(P<0.05),2组患者用药过程中的药物不良反应发生率分别为7.69%、6.25%(P>0.05).结论加替沙星日单次给药治疗呼吸及泌尿系细菌感染的临床疗效显著优于相同日剂量分2次给药疗效,值得推广。
Objective To observe the clinical efficacy of gatifloxacin on respiratory and urinary bacterial infections by single-dose administration, and compare the efficacy of gatifloxacin with twice-daily administration at the same daily dose to explore the effect of gatifloxacin in the treatment of bacterial infections Rational dosing regimen. Methods A total of 142 patients with bacterial infection were randomly divided into groups A and B. Group A received gatifloxacin 0.4 g dissolved in 200 ml of 0.9% sodium chloride injection and then slowly and intravenously. On days 3 and 4, oral administration was changed to 0.4 g qd ; B group gatifloxacin 0.2g dissolved in 0.9% sodium chloride injection 100ml intravenous infusion, bid, 3 days later changed to oral 0.2g, bid, two groups of treatment are 7-10d, the end of the observation treatment Clinical efficiency, bacterial clearance, and various adverse drug reactions occurred in the course of medication, and compared the actual number of days in two groups of patients. Results The clinical effective rates in group A and group B were 93.59% and 87.5%, respectively (P <0.05). The bacterial clearance rate was 95.59% and 87.27% (P <0.05) respectively. The actual medication days in the two groups were 7.2 ± 0.9 and 9.1 ± 1.7 (P <0.05), and the rates of adverse drug reactions in the two groups were 7.69% and 6.25%, respectively (P> 0.05) .Conclusion Gatifloxacin is a single-dose treatment for respiratory and urinary tract bacterial infections The clinical efficacy was significantly better than the same daily dose of 2 doses of efficacy, it is worth promoting.