哺乳动物的精子在实现正常受精之前必需经历顶体反应(acrosome reaction)。典型的顶体反应包含了细胞质和外顶体膜之间的多重融合,通过膜孔使得顶体内含物(各种酶)逸出或暴露。尽管许多研究者设想,人精子顶体反应遵循着这种型式。然而,自1975年以来不少学者对此提出异议。1981年Jamil和White阐明:“外顶体膜呈现囊泡状,而质膜则从顶体结构区向上隆起,并在几处冲破”。 Mammal sperm must undergo an acrosome reaction prior to normal fertilization. A typical acrosome reaction involves multiple fusions between the cytoplasm and the outer acrosomal membrane through which the acrosome contents (various enzymes) escape or are exposed. Although many researchers envision that the acrosome reaction of human sperm follows this pattern. However, many scholars have raised objections to it since 1975. In 1981, Jamil and White clarified: “The outer acrosome is vesicular and the plasma membrane bulges upward from the acrosome and breaks through in several places.”