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目的 了解P2 1对职业性肺癌的预报价值。方法 用WesternBlotting免疫印迹法对2 0名沥青工、焦炉工和 12名对照者血清P2 1水平进行了追踪观察。结果 2 0名沥青工、焦炉工的血清P2 1水平有上下波动现象 ;他们的第 2次P2 1检测值 (3773.3± 10 33.7)高于第 1次 (34 84.4±1915 .8) ,但差异无显著性 (P >0 .0 5 ) ;接触组的这两次P2 1检测值 (34 84.4± 1915 .8、3773.3±10 33.7)始终高于对照组 (1199.8± 75 7.3、12 70 .7± 6 34 .7) ,差异有显著性 (P <0 .0 1)。结论 多环芳烃类混合物具有较强的遗传毒性 ,可使职业工人在早期接触阶段出现P2 1的高表达。
Objective To understand the predictive value of P2 1 in occupational lung cancer. Methods Western blotting was used to observe the level of P2 1 in 20 asphaltenes, coke oven workers and 12 controls. Results The level of P2 1 in 20 asphaltenes and coke oven workers fluctuated up and down. The second P2 1 value (3773.3 ± 10 33.7) was higher than that of the first (34 84.4 ± 1915.8) There was no significant difference between the two groups (P> 0.05). The two detected values of P2 1 in the exposed group (34 84.4 ± 1915.8, 3777.3 ± 1033.7) were always higher than those in the control group (1199.8 ± 75 7.3, 12 70). 7 ± 6 34.7), the difference was significant (P <0.01). CONCLUSION Polycyclic aromatic hydrocarbons (PAHs) mixtures have strong genotoxicity, which can lead to the high expression of P2 1 in workers during the early stage of exposure.