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目的观察用破伤风抗毒素(TAT)脐部封闭治疗新生儿破伤风的效果及不良反应。方法将50例新生儿破伤风随机分配,对照组和治疗组各25例,对照组按常规治疗方法,治疗组在常规治疗基础上加用破伤风抗毒素脐部封闭治疗。结果对照组治愈率60%,治疗组治愈率88%,两组疗效对比,P<0.01,差异有统计学意义。结论现经临床观察,其两组病例对比可证实TAT脐部封闭治疗新生儿破伤风能及时控制痉挛,降低病死率,提高治愈率。
Objective To observe the efficacy and adverse effects of tetanus antitoxin (TAT) in the treatment of tetanus in neonates. Methods 50 cases of neonatal tetanus randomly assigned 25 cases in the control group and the treatment group, the control group according to conventional treatment, the treatment group on the basis of conventional therapy plus tetanus antitoxin umbilical closed treatment. Results The cure rate of the control group was 60%, and the cure rate of the treatment group was 88%. There was significant difference between the two groups (P <0.01). The difference was statistically significant. Conclusion It is clinically observed that the comparison of the two groups of patients confirmed that the TAT umbilical cord closed treatment of neonatal tetanus in time control of spasticity, reduce mortality and improve the cure rate.