神经递质和绝大多数激素(除甾体类激素外)所携带的信息都是通过靶细胞膜受体的作用而实现细胞间信息传递的。随着分子生物学的迅猛发展,关于受体的研究在美国非常活跃,进展十分迅速。近几年关于鸟核苷酸调节蛋白(G 蛋白)方面的研究进展很快,我们研究室已将 Go 提纯并制成抗体,并正在研究其分布。现着重将 G 蛋白在受体-腺苷酸环化酶偶联中的作用进行扼要介绍,同时也介绍 G 蛋白在受体和磷脂酶 C 偶联中的作用。G 蛋白是一种镶嵌于膜中的蛋白质神经递质和大部分激素的受体都是一些位于细胞膜上,能首先与递质和激素等生物小分子相互作 Neurotransmitters and the vast majority of hormones (in addition to steroid hormones) carry the information through the role of the target cell membrane receptors and the realization of cell-to-cell transmission of information. With the rapid development of molecular biology, the research on receptors has been very active in the United States, and the progress is very rapid. In recent years, research on the regulatory proteins of the bird’s nucleotides (G proteins) has progressed rapidly. Our laboratory has purified Go and made antibodies and is studying its distribution. The emphasis is placed on the role of G proteins in receptor-adenylate cyclase conjugation, as well as on the role of G-proteins in receptor-phospholipase C conjugation. G protein is a protein embedded in the membrane neurotransmitter and most of the hormone receptors are some located in the cell membrane, which can be the first with the transmitter and hormone and other biological small molecules interact