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在疫苗生产实践中，细菌污染是影响疫苗质量和产量的关键性因素，笔者通过了两年左右的时间，选取正常生产中零星细菌污染的细胞培养瓶、病毒培养瓶及收毒污染样品等共７０３份，进行细菌学检查，并对造成污染的主要细菌种类进行了各种抗菌药物的耐药性实验，结果表明：①我所脊灰疫苗生产中主要的污染威胁来自环境中的葡萄球菌，潜在威胁是杆菌和链球菌；②强力霉素、林可霉素、配方２、噻孢霉素钠盐、庆大霉素、新霉素、金霉素和红霉素等抗生素对目前引起污染优势细菌－葡萄球菌有明显的抑菌效果，可作为疫苗生产后备抗菌手段参考
In the practice of vaccine production, bacterial contamination is the key factor that affects the quality and yield of the vaccine. The author passed two years or so, select the cell culture flasks, virus culture flasks and contaminated samples from the normal production of sporadic bacteria 703 were tested for bacteriological examination. The antibacterial drug resistance test was conducted on the major bacterial species causing pollution. The results showed that: (1) The main pollution threat in the production of polio vaccine was from the environment of Staphylococcus aureus, Potential threats are bacilli and streptococci; d) Doxycycline, lincomycin, formulation 2, antibiotics such as triclocin sodium, gentamicin, neomycin, chlortetracycline, Bacteria Staphylococcus aureus has obvious bacteriostatic effect, can be used as a backup antibacterial vaccine production reference