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目的探讨脱嘌呤脱嘧啶核酸内切酶/氧化还原因子(APE1/Ref-1)蛋白在胃癌组织中的表达及意义。方法利用组织芯片技术和免疫组化EnVision法检测APE1/Ref-1蛋白在99例胃癌组织中的表达。其中,无淋巴结转移者27例,有淋巴结转移者72例。结果 APE1/Ref-1在胃癌中的阳性表达率为63.64%。其在无淋巴结转移者为37.01%,明显低于有淋巴结转移者的73.61%(P<0.05)。结论 APE1/Ref-1可能通过对增强胃癌组织DNA碱基损伤的修复而参与了胃癌的浸润及转移的机制。
Objective To investigate the expression and significance of APE1 / Ref-1 protein in gastric cancer. Methods The expression of APE1 / Ref-1 protein in 99 gastric cancer tissues was detected by tissue microarray and immunohistochemistry EnVision. Among them, 27 cases without lymph node metastasis, 72 cases with lymph node metastasis. Results The positive rate of APE1 / Ref-1 in gastric cancer was 63.64%. Its lymph node metastasis was 37.01%, significantly lower than those with lymph node metastasis 73.61% (P <0.05). Conclusion APE1 / Ref-1 may be involved in the mechanism of gastric cancer invasion and metastasis by enhancing the repair of DNA damage in gastric cancer.