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目的:观察纳洛酮联合醒脑静注射液治疗急性重度酒精中毒的临床效果。方法:将96例急性重度酒精中毒患者作为研究对象,所有患者均给予常规治疗,包括洗胃、导泻、利尿、纠正水电解质平衡等,按床位单双号分为对照组与观察组各46例。其中对照组采用纳洛酮治疗,观察组联合醒脑静注射液治疗。观察比较两组患者治疗效果及各监测指标变化情况。结果:观察组患者治疗总有效率为97.83%,明显高于对照组的82.61%,差异具有统计学意义(P<0.05);治疗前,两组患者各监测指标均无统计学差异(P>0.05),治疗后观察组患者的RR、瞳孔直径、SBP及PaO2/FiO2均优于对照组(P<0.05)。结论:纳洛酮联合醒脑静注射液可有效治疗急性重度酒精中毒,明显改善患者中毒症状,恢复正常生命体征,值得临床推广应用。
Objective: To observe the clinical effect of naloxone combined with xingnaojing injection in treating acute severe alcoholism. Methods: A total of 96 patients with acute severe alcoholism were selected as study subjects. All patients were given routine treatment, including gastric lavage, cathartic diuresis, diuretic, and water and electrolyte balance. The single and double beds were divided into control group and observation group example. The control group was treated with naloxone, and the observation group was treated with xingnaojing injection. Observed and compared the treatment effect of two groups of patients and the changes of each monitoring index. Results: The total effective rate of observation group was 97.83%, which was significantly higher than that of control group (82.61%), the difference was statistically significant (P <0.05). Before treatment, there was no significant difference between the two groups (P> 0.05). After treatment, RR, pupil diameter, SBP and PaO2 / FiO2 in observation group were better than those in control group (P <0.05). Conclusion: Naloxone combined with xingnaojing injection can effectively treat acute severe alcoholism, significantly improve the symptoms of poisoning and restore normal vital signs, which deserves clinical application.