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目的:观察前列地尔治疗肺结核合并乙肝表面抗原阳性患者化疗所致肝损伤的临床疗效。方法:选取60例2013年6月—2015年6月间我科收治的肺结核合并乙肝表面抗原阳性化疗所致肝损伤患者,随机分为两组,对照组30例在抗结核治疗的基础上给予静脉滴注维生素C 2.0g,门冬氨酸钾镁30mL,肌苷1.0g,每日一次,连续用14天;前列地尔组30例在抗结核治疗的基础上加用前列地尔注射液20μg,加入0.9%氯化钠注射液100mL中静滴,每日一次,疗程14天。每天观察患者临床症状、体征,每3天检测肝功能,ALT、AST、GGT、TBIL。结果:1前列地尔组临床总有效率显著高于对照组;2前列地尔组除乏力外,纳差、腹胀症状的发生率明显低于对照组;3前列地尔组肝功能(ALT、AST、TBIL)恢复情况明显优于对照组。结论:前列地尔治疗肺结核合并乙肝表面抗原阳性患者化疗所致肝损伤疗效确切,有重要的临床应用价值。
Objective: To observe the clinical efficacy of alprostadil in the treatment of chemotherapy-induced liver injury in patients with pulmonary tuberculosis complicated with hepatitis B surface antigen. Methods: Sixty patients with liver injury induced by pulmonary tuberculosis combined with hepatitis B surface antigen-positive chemotherapy in our department from June 2013 to June 2015 were randomly divided into two groups. The control group was given 30 cases on the basis of anti-TB treatment Intravenous infusion of vitamin C 2.0g, potassium aspartate 30mL, inosine 1.0g, once daily for 14 consecutive days; 30 patients in the alprostadil group on the basis of anti-TB treatment with alprostadil injection 20μg, add 0.9% sodium chloride injection 100mL intravenous infusion once daily for 14 days. Patients were observed daily clinical symptoms and signs, liver function tests every 3 days, ALT, AST, GGT, TBIL. The total effective rate in the alprostadil group was significantly higher than that in the control group. 2 The incidence of anorexia and bloating symptoms in the alprostadil group was significantly lower than that in the control group. 3 The alprostadil group (ALT, AST, TBIL) recovery was significantly better than the control group. Conclusion: Alprostadil is effective in treating liver damage induced by chemotherapy in patients with pulmonary tuberculosis complicated with hepatitis B surface antigen. It has important clinical value.