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目的 探讨矽肺以及矽肺结核患者血液黏度和体外血栓的变化。方法 检测 2 88例矽肺患者、178例矽肺结核患者以及 15 0例健康对照者血液黏度和体外血栓的长度和干重。结果 矽肺组和矽肺结核组与正常对照组比较血液黏度 (Ⅰ期矽肺除外 )和体外血栓均显著增高 ,患者各组内Ⅰ、Ⅱ及Ⅲ期间血液黏度亦随期别增加而递增 ,且差异显著 ,体外血栓无显著差异 ;Ⅰ、Ⅱ期矽肺结核患者分别与同期矽肺患者比较 ,全血黏度在高、中剪切率下显著增加 ,在低剪切率下以及血浆黏度差异无显著性 ,体外血栓长度和干重亦增加显著 ;Ⅲ期矽肺结核患者与Ⅲ期矽肺患者比较 ,血液黏度和体外血栓均无显著差异。结论 矽肺患者血液呈高黏、高凝状态 ,且随期别增加血液黏度和体外血栓长度及干重均相应增加 ,合并结核者尤甚。
Objective To investigate the changes of blood viscosity and thrombus in silicosis and silicosis patients. Methods Blood viscosity and in vitro thrombus length and dry weight were detected in 288 cases of silicosis, 178 cases of silicosis and 150 cases of healthy controls. Results Compared with the normal control group, the blood viscosity (except silicosis stage I) and thrombus in silicosis group were significantly higher than those in the normal control group. The blood viscosity of Ⅰ, Ⅱ and Ⅲ in each group also increased with the increase of the stage, and the difference was significant , In vitro thrombosis no significant difference; Ⅰ, Ⅱ silicosis patients with silicosis in the same period compared with the same period, the whole blood viscosity at high and medium shear rate significantly increased at low shear rate and plasma viscosity was no significant difference in vitro Thrombus length and dry weight also increased significantly; stage Ⅲ silicosis patients with stage Ⅲ silicosis patients, blood viscosity and in vitro thrombosis no significant difference. Conclusions The blood of patients with silicosis is highly viscous and hypercoagulable. With the increase of blood viscosity, the length of thrombus in vitro and dry weight are correspondingly increased, especially in patients with tuberculosis.