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采用吗啡不同剂量和给药途径治疗急性肺水肿50例,临床和血气分析结果显示:静脉用药(吗啡4mgiv)患者缺氧缓解时间快,血氧饱和度(SaO_2)和氧分压(PaO_2)回升明显,呼吸抑制发生较少,与肌肉和皮下用药比较3组差异显著(P<0.05)。提示吗啡治疗急性肺水肿应早期、静脉和足量的原则,较佳剂量为4~5mgiv,并对吗啡的治疗作用作了初步分析。
Fifty patients with acute pulmonary edema were treated with different doses and route of morphine. The results of clinical and blood gas analysis showed that the patients with intravenous drug (morphine 4 mgiv) had faster hypoxia response time, blood oxygen saturation (SaO_2) and oxygen partial pressure (PaO_2) Obviously, respiratory depression occurred less, compared with the muscle and subcutaneous administration 3 significant differences (P <0.05). Prompt morphine treatment of acute pulmonary edema should be early, intravenous and adequate principle, the best dose of 4 ~ 5mgiv, and morphine for the treatment of a preliminary analysis.