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目的 :比较 3种左旋多巴片剂 (A、B和 C片 )的生物利用度和药物动力学。方法 :8名健康志愿者分别单剂量口服 2 0 0mg 3种药物 ,血药浓度由本实验室改进的高效液相色谱法测得。结果 :左旋多巴的药 -时曲线符合二室模型 ,A、B和 C片的 tmax分别为 (4 8.47± 13.86 )、(15 2 .6 5± 46 .71)和 (31.38± 7.74) min;cmax分别为 (3.17± 1.0 7)、(1.0 4± 0 .42 )和 (3.5 5± 0 .91)︼g/ml;AUC0→∞ 分别为 (4 2 4.44± 6 7.5 0 )、(2 97.36± 5 2 .18)和 (4 0 6 .0 9± 85 .0 2 ) ︼g· m l/ min。B和 C片相对于 A片的相对生物利用度分别为 (70 .17± 7.41) %和 (97.6 3± 11.94) %。结论 :B片较 A片有达峰时间长、峰浓度低的特点 ,C片与 A片相比具有吸收快、达峰时间短的特点。
OBJECTIVE: To compare the bioavailability and pharmacokinetics of three levodopa tablets (tablets A, B and C). Methods: Eight healthy volunteers were given a single oral dose of 200 mg three kinds of drugs, the plasma concentration measured by the laboratory improved high performance liquid chromatography. Results: The drug-time curve of levodopa conformed to the two-compartment model, and the tmax of A, B and C tablets were (4 8.47 ± 13.86), (15.26 ± 46.71) and (31.38 ± 7.74) min ; cmax were (3.17 ± 1.07), (1.04 ± 0.42) and (3.55 ± 0.91) ︼g / ml respectively; AUC0 → ∞ were (4 2 4.44 ± 6 7.5 0), 97.36 ± 5 2 .18) and (4 0 6 .0 9 ± 85 .0 2) ︼g · ml / min. The relative bioavailability of B and C tablets relative to A tablet were (70.17 ± 7.41)% and (97.6 3 ± 11.94)%, respectively. Conclusion: Compared with A film, B film has the characteristics of long peak time and low peak concentration. Compared with A film, C film has the characteristics of fast absorption and short peak time.