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Objectives.-To review and describe the anatomoclinical cases of the endometrial cancers arising on polyps during a hormonotherapy by tamoxifen for breast cancer. Patients and methods.-In the surgical inventory 1990-2002 of the benign or malignant uterine lesions investigated by hysteroscopy with dilatation &curettage (D&C) and/or hysterectomy, 108 single or multiple endometrial polyps were encountered and histologically analyzed. Results.-A malignant transformation of polyp was found in 5 instances, meaning a rate of 4.6%i.e. 5/108: 4 cases of adenocarcinoma, 1 case of sarcoma. Discussion and conclusion.-The existence of endometrial polyps-symptomatic or not-does not seem compatible with the prolonged use of tamoxifen treatment owing the estrogen agonist potential effects of tamoxifen and its well-known hyperplastic and carcinogenic properties for the endometrium. The increased risk of endometrial cancer developing in polyps in this iatrogenic context is estimated between 2.5%and 10%in the literature.
Objectives-To review and describe the anatomoclinical cases of the endometrial cancers arising on polyps during a hormonotherapy by tamoxifen for breast cancer. Patients and methods.-In the surgical inventory 1990-2002 of the benign or malignant uterine lesions investigated by hysteroscopy with dilatation Results & nbsp; A curenttage of polyp was found in 5 instances, meaning a rate of 4.6% ie 5/108: 4 cases of adenocarcinoma , 1 case of sarcoma. Discussion and conclusion. -The existence of endometrial polyps-symptomatic or not-does not seem compatible with the prolonged use of tamoxifen treatment owing the estrogen agonist potential effects of tamoxifen and its well-known hyperplastic and carcinogenic properties for the endometrium. The increased risk of endometrial cancer developing in polyps in this iatrogenic context is estimated between 2.5% and 10% in the literature.