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目的观察甘氨双唑钠(CM-Na)联合同期放化疗对局部晚期非小细胞肺癌(NSCLC)的近期疗效及毒副作用。方法将72例局部晚期NSCLC患者随机分为CM-Na组(34例)和对照组(38例)。放射治疗采用常规放疗,剂量5600～6000cGy;同步化疗采用长春瑞宾(盖诺)+顺铂NP方案化疗4周期。对照组采用单纯放化疗,CM-Na组采用同步放化疗联合CM-Na治疗。2组同步放化疗方案相同。结果 CM-Na组患者的完全缓解率(CR)和有效率(PR+CR)分别为17.6%、76.5%,对照组患者的CR率和有效率分别为7.9%、52.6%,2组疗效比较差异有统计学意义(P均<0.05);2组的毒副反应相似。结论 CM-Na联合NP方案同步化放疗可提高局部晚期NSCLC的肿瘤消退率,提高近期疗效,其急性毒副反应可耐受。
Objective To observe the short-term curative effect and toxicity of CM-Na combined with concurrent chemoradiotherapy on locally advanced non-small cell lung cancer (NSCLC). Methods 72 patients with locally advanced NSCLC were randomly divided into CM-Na group (34 cases) and control group (38 cases). Radiotherapy using conventional radiotherapy, the dose of 5600 ~ 6000cGy; synchronous chemotherapy with vinorelbine (Gauno) + cisplatin NP chemotherapy 4 cycles. The control group received radiotherapy and chemotherapy alone. The CM-Na group was treated with concurrent chemoradiotherapy combined with CM-Na. 2 sets of concurrent chemoradiation programs the same. Results The complete remission rate (CR) and effective rate (PR + CR) of patients in CM-Na group were 17.6% and 76.5%, respectively. The CR rate and effective rate in control group were 7.9% and 52.6% The difference was statistically significant (P <0.05); 2 groups of similar side effects. Conclusions CM-Na combined with NP regimen can improve the tumor regression rate of locally advanced NSCLC and improve the short-term curative effect. The acute toxicities and side effects can be tolerated.