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目的:探究清肝宁肺汤治疗咳嗽变异性哮喘(CVA)的部分作用机制。方法:利用卵蛋白(OA)及辣椒素,复制CVA大鼠模型,分为正常对照组、模型对照组、地塞米松片组、清肝宁肺汤组、地塞米松片合清肝宁肺汤组(以下简称为中西医结合组),以引喘诱咳时2min内大鼠咳嗽次数及血清中IL-6、IgE及ICAM-1的含量为指标。结果:与正常对照组比较,模型对照组咳嗽次数明显增多(P<0.01),血清中IgE、IL-6、ICAM-1含量显著升高(P<0.01)。经治疗后清肝宁肺汤组咳嗽次数明显减少(P<0.01),血清上述指标含量明显降低(P<0.01)。结论:清肝宁肺汤通过降低机体IgE、IL-6、ICAM-1的含量发挥治疗CVA作用。
Objective: To explore the mechanism of Qingganningfei Decoction in treating cough variant asthma (CVA). Methods: The model rats were divided into normal control group, model control group, dexamethasone group, Qinggan Ningpi Decoction group, dexamethasone tablet and Qingganning lung by using ovalbumin (OA) and capsaicin Soup group (hereinafter referred to as Integrative Medicine Group), to induce asthma induced cough within 2min cough frequency and serum IL-6, IgE and ICAM-1 content as an indicator. Results: Compared with the normal control group, the number of coughs in the model control group was significantly increased (P <0.01), and the levels of IgE, IL-6 and ICAM-1 in serum were significantly increased (P <0.01). After treatment, the number of cough in Qingganningfei Decoction group was significantly decreased (P <0.01), and the above indexes in serum were significantly decreased (P <0.01). Conclusion: Qingganningfei Decoction can treat CVA by decreasing the levels of IgE, IL-6 and ICAM-1.