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目的 探讨急性髓细胞白血病 (AML)的细胞遗传学改变及与诊断、治疗、预后的关系。方法 对 2 2 5例初治AML的患者进行骨髓染色体分析 ,采用短期培养法制备骨髓细胞染色体G显带。结果 发现本组 131例 ( 5 8.2 % )有克隆性染色体异常。共有 14种核型异常。t( 15 ;17)、t( 8;2 1)、t( 9;2 2 )为最常见的结构异常 ,且t( 15 ;17)、t( 8;2 1)、inv( 16 )分别仅见于M3 、M2 、M4E0 。核型异常与临床完全缓解率 ,完全缓解持续时间及中位生存期等预后高度相关 ,t( 15 ;17)、t( 8;2 1)完全缓解率高 ,完全缓解期及中位生存期长 ,预后相对较好。而正常核型次之 ,其它核型异常预后较差。结论 染色体研究对AML的诊断 ,分型 ,治疗选择及预后估计均有重要意义。
Objective To investigate the cytogenetic changes of acute myeloid leukemia (AML) and its relationship with diagnosis, treatment and prognosis. Methods Bone marrow chromosome analysis was performed in 225 untreated AML patients. Chromosome G banding of bone marrow cells was prepared by short-term culture. The results showed that 131 cases (5 8.2%) had clonal chromosome abnormalities. A total of 14 karyotype abnormalities. t (15; 17), t (8; 2 1), t (9; 2 2) are the most common structural anomalies, and t Only seen in M3, M2, M4E0. Karyotype abnormalities were highly correlated with the prognosis of complete remission, complete remission duration and median survival. The complete remission rates of t (15; 17), t (8; 21), complete remission and median survival Long, the prognosis is relatively good. The normal karyotype, followed by poor prognosis of other karyotype. Conclusion Chromosome research is of great significance for the diagnosis, classification, treatment options and prognosis of AML.