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[目的]探讨胎盘多肽注射液在Ⅲ、Ⅳ期非小细胞肺癌(NSCLC)化疗中的作用。[方法]经病理学或细胞学检查确诊的Ⅲ、Ⅳ期NSCLC患者随机分为治疗组与对照组。治疗组48例,采用胎盘多肽注射液联合吉西他滨+顺铂方案化疗;对照组50例,单纯采用吉西他滨+顺铂方案化疗。每4周为1个周期,化疗4个周期。每2个周期评价疗效,监测治疗前后患者外周血白细胞(WBC)、血小板(PLT)、T细胞亚群及血清免疫球蛋白(Ig)含量变化。[结果]治疗组和对照组有效率分别为52.1%和48.0%(P>0.05)。治疗组胃肠道反应和骨髓抑制较对照组轻,差异有统计学意义(P<0.05)。化疗后治疗组CD8+和CD4+/CD8+较对照组高,差异有统计学意义(P<0.05)。治疗组化疗后KPS评分明显高于对照组(P<0.05)。化疗后治疗组血清IgM和IgG含量与对照组比较,差异有统计学意义(P<0.05)。[结论]胎盘多肽注射液联合吉西他滨+顺铂方案治疗Ⅲ、Ⅳ期NSCLC疗效较好,患者不良反应轻,且具有提高机体的免疫功能和改善患者生活质量的作用。
[Objective] To investigate the role of placental peptide injection in chemotherapy of stage Ⅲ and Ⅳ non-small cell lung cancer (NSCLC). [Methods] Patients with stage Ⅲ and Ⅳ NSCLC diagnosed by pathology or cytology were randomly divided into treatment group and control group. The treatment group of 48 cases, using placental peptide injection combined with gemcitabine + cisplatin chemotherapy; control group of 50 patients, simple chemotherapy with gemcitabine + cisplatin. Every 4 weeks for a cycle, chemotherapy 4 cycles. The curative effect was evaluated every 2 cycles. The changes of WBC, PLT, T lymphocyte subsets and serum immunoglobulin (Ig) were monitored before and after treatment. [Results] The effective rates of the treatment group and the control group were 52.1% and 48.0%, respectively (P> 0.05). The gastrointestinal tract reaction and myelosuppression in the treatment group were lighter than those in the control group, with significant difference (P <0.05). After chemotherapy, the levels of CD8 + and CD4 + / CD8 + in the treatment group were significantly higher than those in the control group (P <0.05). The KPS score of the treatment group after chemotherapy was significantly higher than that of the control group (P <0.05). After chemotherapy, serum IgM and IgG levels in the treatment group were significantly different from those in the control group (P <0.05). [Conclusion] Placental peptide injection combined with gemcitabine plus cisplatin regimen in the treatment of stage Ⅲ and Ⅳ NSCLC has better curative effect, less adverse reactions, and has the function of improving the immune function and improving the quality of life of patients.