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目的探讨雌激素受体 (ER)在新辅助化疗中乳腺癌组织表达的预期意义。方法采用免疫组织化学法检测 14 2例乳腺癌组织中ER的表达状况 ,并分析其在新辅助化疗中的预期意义。结果ER的表达与肿瘤的临床化疗反应显著相关 (P <0 .0 1) ,新辅助化疗前后ER的表达无明显变化 (P >0 .0 5 )。结论ER在新辅助化疗乳腺癌患者中有重要的预期意义 ,在决定化疗后患者是否行内分泌治疗时 ,应考虑化疗对ER功能的影响。
Objective To investigate the significance of estrogen receptor (ER) expression in breast cancer tissue in neoadjuvant chemotherapy. Methods Immunohistochemistry was used to detect the expression of ER in 14 2 cases of breast cancer and its significance in neoadjuvant chemotherapy was analyzed. Results The expression of ER was significantly correlated with the clinical response to chemotherapy (P <0.01). The expression of ER did not change significantly before and after neoadjuvant chemotherapy (P> 0.05). Conclusion ER plays an important role in neoadjuvant chemotherapy for patients with breast cancer. The effect of chemotherapy on ER function should be considered in deciding whether patients should undergo endocrine therapy after chemotherapy.