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本研究通过复制家兔失血性休克模型，探讨失血性休克后家兔血浆内皮素（ET）、肿瘤坏死因子（TNF）的活性，及应用促甲状腺素释放激素（TRH）后ET、TNF的变化．结果表明，失血性休克家兔血浆ET浓度明显升高，与休克前相比较有显著性差异（P＜0．05）。TNF在失血性休克后与休克前相比较亦有显著上升（P＜0．05）。Ⅱ组应用TRH后，于4h、8h时相血浆ET水平与失血性休克组同时相比较有显著下降（P＜0．01）。TNF则无明显差异。提示ET、TNF为失血性休克的重要因素，应用TRH治疗可显著降低血浆ET浓度，可能为其抗休克作用的重要机制之一。
In this study, the rabbit model of hemorrhagic shock was duplicated to investigate the changes of plasma ET, TNF, ET and TNF after hemorrhagic shock in rabbits, and the changes of ET and TNF after application of thyrotropin-releasing hormone (TRH) . The results showed that the concentration of ET in hemorrhagic shock rabbits significantly increased compared with that before shock (P <0.05). TNF in hemorrhagic shock after shock compared with a significant increase (P <0.05). Compared with the hemorrhagic shock group, the level of ET in group Ⅱ was significantly decreased at 4h and 8h (P <0.01). TNF was no significant difference. It is suggested that ET and TNF are important factors of hemorrhagic shock. Treatment with TRH can significantly decrease plasma ET level, which may be one of the important mechanisms of anti-shock.