爵床科植物 Justicia simples D.Don 是喜马拉雅山西部民间的著名延年益寿药用植物。作者从该植物中分得一个新的三萜皂甙,命名为 justicisaponin-I。药理实验证实其通过对精子顶体膜的稳定作用,干扰精子中酸性水解酶和蛋白质的释放,从而阻止卵细胞受精,因此,justicisaponin-I 可能是一个有效抗生育剂。 Justicia simples D.Don is a famous longevity medicinal plant in western Himalayas. The authors assigned a new triterpenoid saponin from the plant named justicisaponin-I. Pharmacological experiments confirmed that it stabilizes the acrosome of sperm and interferes with the release of acid hydrolases and proteins in the sperm and thus inhibits egg cell fertilization. Therefore, justicisaponin-I may be an effective anti-fertility agent.