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目的探讨盐酸利托君和硫酸镁治疗对先兆早产患者血清一氧化氮(NO)、白介素-6(IL-6)、前列腺素E_2(PGE_2)水平的影响。方法选取2013年9月-2016年9月该院确诊治疗的先兆早产患者100例,依据随机数表法分为联合组和对照组,每组各50例,对照组患者给予硫酸镁静脉滴注治疗,联合组患者在此基础上给予盐酸利托君静脉滴注治疗,采用酶联免疫吸附法(ELISA)检测血清NO、IL-6、PGE_2水平,采用阿氏评分(Apgar)评估新生儿窒息,比较两组患者治疗前后血清NO、IL-6、PGE_2水平、宫缩消失时间、延长妊娠时间、保胎、新生儿体重、Apgar评分和不良反应发生情况。结果联合组患者治疗后血清NO、IL-6、PGE_2水平明显低于对照组,差异有统计学意义(P<0.05);联合组患者延长妊娠时间、保胎成功率、新生儿体重、Apgar评分均明显高于对照组,宫缩消失时间明显低于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率差异无统计学意义(P>0.05)。结论盐酸利托君联合硫酸镁治疗可有效改善先兆早产患者的妊娠和新生儿结局,其机制可能与调节血清NO、IL-6、PGE_2水平有关,具有良好的安全性。
Objective To investigate the effects of Rituxan and Magnesium Sulfate on the levels of serum nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in preterm labor. Methods From September 2013 to September 2016, 100 patients with threatened preterm birth who were diagnosed and treated in our hospital from September 2013 to September 2016 were divided into the control group and the combination group according to the random number table, 50 patients in each group. The patients in the control group were given intravenous infusion of magnesium sulfate The patients in the combined group were treated with intravenous drip therapy with Rituxan Hydrochloride. Serum NO, IL-6 and PGE 2 levels were measured by enzyme-linked immunosorbent assay (ELISA), Apgar was used to evaluate neonatal asphyxia The levels of serum NO, IL-6, PGE 2, disappearance of contractions, prolonged pregnancy, miscarriage, newborn weight, Apgar score and adverse reactions were compared between the two groups before and after treatment. Results The serum levels of NO, IL-6 and PGE_2 in the combined group were significantly lower than those in the control group (P <0.05). The prolongation of gestation time, the success rate of miscarriage, neonatal weight, Apgar score (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The combination of lithotripsy and magnesium sulfate can effectively improve the outcome of pregnancy and newborn in preterm labor. The mechanism may be related to the regulation of serum NO, IL-6 and PGE_2 levels and has good safety.