多系统萎缩(multiple systematrophy,MSA)又称多系统变性。此概念提出于1969年[1],它是指一组在临床表现和病理改变上具有很大相似性的临床病理综合征,为神经系统变性疾病。由于该病发病率和患病率均较低,疾病的病程中以神经系统部位受累的临床表现为首发症状,经常以某一系统损 Multi-system atrophy (MSA), also known as multi-system degeneration. This concept was proposed in 1969 [1], it refers to a group of clinical pathology and pathological changes have a great similarity in clinical pathological syndrome, a degenerative disease of the nervous system. As the incidence and prevalence of the disease are low, the course of the disease in the nervous system involvement of the clinical manifestations as the first symptom, often with a system loss