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随着乙胺碘呋酮应用的日益增多,其副作用屡有报道,发生率约44%。现将近年来有关该药的毒副反应综述如下。 一、心血管系统 根据各家报道无论是口服,静注或静滴本药均可引起心血管毒副反应。 (一)心动过缓:其发生率14.0~92.6%,心律最慢可减至30次/分以下,且不能被阿托品所纠正。 (二)传导阻滞:发生率4.0~16.7%,如窦房阻滞、Ⅰ、Ⅱ和高度房室传导阻滞、房或室内阻滞,不完全和完全性右或左束支阻滞等。
With the increasing use of amiodarone, its side effects have been repeatedly reported, the incidence of about 44%. In recent years, the drug side effects are summarized below. First, the cardiovascular system According to various reports, whether oral, intravenous or intravenous infusion of this drug can cause cardiovascular toxicity. (A) bradycardia: the incidence of 14.0 ~ 92.6%, the slowest heart rate can be reduced to 30 beats / min, and can not be corrected by atropine. (B) block: the incidence of 4.0 to 16.7%, such as sinoatrial block, Ⅰ, Ⅱ and atrioventricular block, atrial or ventricular block, incomplete and complete right or left bundle branch block, etc. .