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为探讨ＨＩＥ脑组织脂质过氧化的改变及丹参的保护作用，用生后七日ＳＤ大鼠制成ＨＩＥ模型，在模型后不同时刻检验脑组织内丙二醛（ＭＤＡ）及谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）的动态变化，利用丹参进行实验性治疗。结果显示（１）ＨＩＥ后 ２小时ＭＤＡ显著升高（１．７１±０．１９，Ｐ＜０．０１），１２小时达高峰（１．９７±０．２９，Ｐ＜０．０１）７２小时后恢复正常（１．３２±０．０９，Ｐ＞０．０５）；ＧＳＨ－ＰＸ２小时显著降低（１．２９±０．４３，Ｐ＜０．０１），以后渐升高，但 ４８小时（２．２２±０．８１）与对照组（３．３４±０．３４）相比仍有统计学差异（Ｐ＜０．０５），７２小时恢复正常（２．４５±０．９０，Ｐ＞０．０５）；丹参治疗组ＭＤＡ显著降低（１．３９±０．３７，Ｐ＜０．０１），ＧＳＨ－ＰＸ显著升高（２．４２±０．６２，Ｐ＜０．０５）。表明脑组织内脂质过氧化增强、抗氧化减弱参与ＨＩＥ的发病机制，丹参具有抗氧化作用，能减轻脑组织水肿、出血及坏死，有临床应用价值。
In order to investigate the changes of lipid peroxidation in HIE and protective effects of Salvia miltiorrhiza in HIE rats, HIE model was made on SD rats on the 7th day after birth. Malondialdehyde (MDA) and glutathione Peroxidase (GSH-PX) in the dynamic changes, the use of Salvia for experimental treatment. The results showed that: (1) MDA increased significantly at 2 hours after HIE (1.71 ± 0.19, P <0.01) and peaked at 12 hours (1.97 ± 0.29, P <0.01) (1.32 ± 0.09, P> 0.05). GSH-PX2 hours decreased significantly (1.29 ± 0.43, P <0.01) (2.22 ± 0.81) and control group (3.34 ± 0.34) (P <0.05), and returned to normal at 72 hours (2.45 ± 0.90, P> 0.05). MDA in Salvia miltiorrhiza group was significantly lower (1.39 ± 0.37, P <0.01) and GSH-PX was significantly higher (2.42 ± 0.62, P <0.05). It is indicated that lipid peroxidation in brain tissue is enhanced and antioxidation is weakened in the pathogenesis of HIE. Salvia miltiorrhiza possesses anti-oxidation effect, which can relieve edema, hemorrhage and necrosis of brain tissue and has clinical value.