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探讨如何减少手术对垂体瘤患者造成的创伤，从而达到微创伤或低创伤治疗。方法：对１２例患者在鼻内窥镜下进行经鼻腔－蝶窦垂体瘤切除术。全麻，内窥镜下经一侧鼻腔、蝶窦入路，打开鞍底骨质及硬脑膜，直视下切除肿瘤。结果：除１例二次手术的生长激素腺瘤患者死于术后颅内出血外，其余恢复顺利。随访７个月～１．５年，有９例内分泌指标恢复正常，其中８例术前存在视力障碍者，术后均有不同程度的恢复。结论：内窥镜具有照明好，视野清楚之优点，临床应用不仅能提高手术的准确性和安全性，还能减少对正常组织的损伤。
To explore how to reduce trauma caused by surgery in patients with pituitary tumors, so as to achieve minimally invasive or low trauma treatment. Methods: Thirteen patients underwent nasal-sphenoidal pituitary tumor resection under nasal endoscopy. General anesthesia, endoscopic nasal by the side, sphenoid sinus approach, open the saddle bone and dura, resection of the tumor under direct vision. Results: Except for 1 case of secondary growth hormone adenoma died of postoperative intracranial hemorrhage, the rest recovered smoothly. Followed up for 7 months to 1.5 years, 9 cases of endocrine indicators returned to normal, including 8 cases of preoperative visual impairment, postoperative have varying degrees of recovery. Conclusion: The endoscope has the advantages of good illumination and clear vision. The clinical application not only can improve the accuracy and safety of the operation, but also reduce the damage to the normal tissue.