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目的:探讨检测肿瘤标志物癌胚抗原(CEA)、糖抗原19-9(CA19-9)对鉴别良恶性腹水的诊断价值。方法:比较两组患者76例腹水CEA、CA19-9的情况。结果:恶性腹水组CEA、CA19-9水平较良性腹水组显著升高(P<0.01)。CEA、CA19-9诊断恶性腹水的敏感性分别为75.0%,65.63%,特异性分别为88.64%,90.91%。CEA及CA19-9联合检测可提高诊断恶性腹水的敏感性至91.41%。结论:检测CEA、CA19-9有助于良恶性腹水的鉴别诊断。
Objective: To investigate the diagnostic value of detection of tumor marker carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in differential diagnosis of benign and malignant ascites. Methods: 76 patients with ascites CEA, CA19-9 were compared between the two groups. Results: The levels of CEA and CA19-9 in malignant ascites group were significantly higher than those in benign ascites group (P <0.01). The sensitivity of CEA and CA19-9 in the diagnosis of malignant ascites were 75.0% and 65.63% respectively, and the specificity was 88.64% and 90.91% respectively. CEA and CA19-9 joint detection can improve the sensitivity of malignant ascites diagnosis to 91.41%. Conclusion: The detection of CEA, CA19-9 is helpful for the differential diagnosis of benign and malignant ascites.