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对喉声带重度非典型增生和原位癌中表皮生长因子受体(EGFR)的表达情况进行研究。14例喉活检标本,病理证实为重度非典型增生或原位癌,经福尔马林固定,石蜡包埋,5μm切片,以鼠抗表皮生长因子受体单抗行ABC免疫组织化学染色。14例重度非典型性增生或原位癌都表现为EGFR阳性反应。5例区域性中度非典型增生,3例EGFR表现为有散在细胞阳性反应,2例为阴性,14例中8例有区域性轻度非典型增生,EGFR反应阴性。对两组病人进行了随访,结果表明:增生及轻度非典型增生的病例发展成重度非典型增生或浸润癌的发生率为4%(4/98)和6%(8/24),
We studied the expression of epidermal growth factor receptor (EGFR) in severe atypical hyperplasia of throat and in situ carcinoma. Fourteen cases of laryngeal biopsy specimens were pathologically confirmed as severe atypical hyperplasia or carcinoma in situ and formalin-fixed, paraffin-embedded, and 5-μm sections were screened for ABC immunohistochemical staining using mouse anti-EGFR monoclonal antibody. 14 cases of severe atypical hyperplasia or carcinoma in situ showed EGFR positive reaction. 5 cases of regional moderate atypical hyperplasia, 3 cases of EGFR showed scattered positive cells, 2 cases were negative, 14 cases of 8 cases of mild regional atypical hyperplasia, EGFR negative. Two groups of patients were followed up. The results showed that the incidence of severe atypical hyperplasia or invasive carcinoma was 4% (4/98) and 6% (8/24) in patients with hyperplastic and mild atypical hyperplasia,