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近年来,不少学者根据大量研究工作,对 Burnet 提出的关于“白我识别”的设想进行了进一步探讨,并就“自我识别”和自身免疫问题发表了一些新的见解。事实证明,针对自身抗原的许多免疫活性细胞,并没有在胚胎期被消灭,而是持续存在直至成年;它们也不一定都是 Burnet 所想象的“禁株”。它们之所以不破坏自身抗原,或者机体之所以对这些自身抗原具有免疫耐受性,可能是因为:(1)抑制性T 细胞抑制了这些针对自身抗原的免疫活性细胞;(2)一定剂量的某些自身抗原可以使相应的 T 细胞或 B 细胞处于免疫耐受状态。如果因抑制性 T 细胞不足等因素造成免疫耐受性的障碍,就可发生自身免疫性疾病。
In recent years, many scholars based on a large amount of research work, further discussed Burnet’s vision of “white identification” and put forward some new opinions on the issue of “self-identification” and autoimmunity. It turns out that many of the immune-competent cells that target their own antigens are not eliminated during the embryo, but persist until they reach adulthood; neither are they all necessarily “banned” by Burnet’s imagination. The reason why they do not destroy self antigens or the body is immunologically tolerant to these autoantigens may be due to: (1) inhibitory T cells inhibit these immune-competent cells against autoantigens; (2) a dose of Some autoantigens can put the corresponding T cells or B cells in an immune tolerant state. Autoimmune diseases can occur if there is an obstacle to immune tolerance due to factors such as insufficient suppressor T cells.