论文部分内容阅读
口服8-甲氧基补骨脂素(8-MOP)约2小时后照射紫外线(320～400毫微米)已愈来愈多地应用于治疗银屑病。血浆8-MOP的浓度和皮肤的光敏感性有密切关系。由于许多药物的动力学特性可受食物的影响,因而作者研究了食物对8-MOP的动力学作用。对5名健康男性受试者,在禁食情况下和吃过统一标准早餐后,分别给予8-MOP40毫克糖衣片。非禁食者的这种统一早餐包括:150毫升的低脂牛奶,100毫升桔子汁,100毫升无糖黑咖啡;一个鸡蛋,2片烘面包,5克人造奶油,20克桔子果酱和
UV irradiation (320-400 nm) after oral administration of 8-methoxy psoralen (8-MOP) for about 2 hours has been increasingly used to treat psoriasis. The plasma concentration of 8-MOP is closely related to the photosensitivity of the skin. Since many of the pharmacokinetic properties are influenced by food, the authors studied the kinetics of food on 8-MOP. Five healthy male subjects were given 8-MOP 40 mg tablets under fasting and after eating a uniform standard breakfast. This uniform breakfast for non-fasted people includes 150 ml of low-fat milk, 100 ml of orange juice, 100 ml of sugar-free black coffee, 1 egg, 2 bakeries, 5 g margarine, 20 g orange jam and