目的评价深圳市某社区15岁以下人群规范全程接种乙肝疫苗1年后的免疫水平。方法对某社区经检测HBsAg阴性的15岁以下人员按“0、1、6”程序接种乙肝疫苗,符合全程规范接种要求的1 986例对象在接种疫苗1年后进行抗-HBs定性和定量检测。结果 (1)在该小区建立有健康档案的15岁以下各组人群乙肝疫苗全程接种率均在95%以上,平均为96.18%。(2)该1 986名研究对象在接种乙肝疫苗1年后检测抗-HBs,平均抗体阳性率为93.06%,抗-HBs几何平均浓度为267.89 mIU/ml。新生儿组、学龄前组、小学组和初中组抗-HBs阳性率分别为96.46%,94.32%,92.75%和90.02%;平均抗体浓度分别为312.17 mIU/ml,290.33 mIU/ml,265.13 mIU/ml和218.44mIU/ml,组间差异有统计学意义(P<0.05)。随着疫苗接种年龄的增大,抗-HBs阳性率和抗体浓度有下降趋势。(3)新生儿组、学龄前组、小学组和初中组抗-HBs阳性率和平均抗体浓度男性之间和女性之间组间差异有统计学意义(P<0.05)。但同年龄组男女性之间差异无统计学意义(P>0.05)。结论 15岁以下人员接种乙肝疫苗免疫效果良好,年龄越小接种,保护性作用越大。 Objective To evaluate the immunization level of a group of 15-year-olds in Shenzhen who regulated the whole course of hepatitis B vaccine one year after inoculation. Methods One hundred and eighty-six HBsAg-negative individuals under the age of 15 were vaccinated with hepatitis B vaccine according to the procedure of “0,1,6 ”, and 1 986 subjects who met the standard norms of vaccination were screened for anti-HBs one year after vaccination Quantitative detection. Results (1) Hepatitis B vaccine throughout the entire population of people under the age of 15 in the district with a health record was above 95% with an average of 96.18%. (2) The anti-HBs were detected in 1 986 subjects one year after inoculation of hepatitis B vaccine. The average antibody positive rate was 93.06% and the average geometric mean concentration of anti-HBs was 267.89 mIU / ml. The positive rates of anti-HBs in neonatal group, preschool group, primary school group and junior high school group were 96.46%, 94.32%, 92.75% and 90.02% respectively. The average antibody concentrations were 312.17 mIU / ml, 290.33 mIU / ml and 265.13 mIU / ml and 218.44mIU / ml, the difference was statistically significant (P <0.05). With the increase of vaccination age, anti-HBs positive rate and antibody concentration have a downward trend. (3) The positive rate of anti-HBs and the average antibody concentration of neonates, preschools, primary schools and junior middle schools were significantly different between male and female groups (P <0.05). However, there was no significant difference between men and women in the same age group (P> 0.05). Conclusion The vaccination of hepatitis B vaccine under 15 years old is effective. The younger the vaccination, the greater the protective effect.