由于胰岛素、抗生素等药物在临床上的广泛应用,糖尿病的急性并发症,例如酮症酸中毒、非酮症高渗性昏迷、感染等已能得到有效的控制,而其慢性并发症则已成为糖尿病患者致残或致死的主要原因。许多资料表明,在多种慢性并发症中,如视网膜病变、肾病、心肌病变、神经病变及皮肤病变等,微血管病变是重要的病理基础。因此,对糖尿病微血管病变的研究越来越为人们所重视。微血管系指介于微小动脉和微小静脉之间,管径小于100μm的微细血管网,包括毛细血管、极微细的动脉和静脉,是血液与组织之间物质交换的重要场所,也是各组织器官内最小的功能——形态联系单位。糖尿病微血管病变的形态学特点为毛细血管基底膜增厚,可见于皮肤、骨胳肌、脂肪组织、肾、胰和末梢神经等,是随糖尿病迁延而发展的。通常认为,这种损害为糖尿病所特有,但晚 As insulin, antibiotics and other drugs in the clinical widely used, acute complications of diabetes, such as ketoacidosis, nonketotic hyperosmolar coma, infection, etc. have been effectively controlled, and its chronic complications have become The main cause of disability or death in diabetic patients. Many data show that in a variety of chronic complications, such as retinopathy, nephropathy, cardiomyopathy, neuropathy and skin lesions, microvascular disease is an important pathological basis. Therefore, the study of diabetic microangiopathy has drawn more and more attention. Microvascular refers to the micro vascular network between the small artery and the tiny vein, the diameter less than 100μm, including capillaries, very fine arteries and veins, is an important place for the exchange of material between the blood and the tissue, and also within the tissues and organs The smallest feature - the form of contact units. Diabetic microangiopathy morphological features of the capillary basement membrane thickening, can be found in the skin, skeletal muscle, adipose tissue, kidney, pancreas and peripheral nerves, etc., is the development of diabetes mellitus. It is generally assumed that this damage is unique to diabetes, but late