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解放军军事医学科学院放射与辐射医学研究所,首次在国际上揭示泛素连接酶Smurf1是促进结直肠癌发生、发展,并且导致病人预后差的一个重要因子,论文在线发表在5月13日英国《自然-通讯》。此前学术界揭示的这种连接酶均为锌指类型,而Smurf1则属于全新类型的连接酶,两者作用机制不同,并且Smurf1所代表的模式从酵母到哺乳动物都是保守存在的,这为深入理解类泛素化修饰的生物学意义与作用
PLA Institute of Radiation Medicine and Radiation Medicine, for the first time in the world revealed that ubiquitin ligase Smurf1 is to promote the occurrence and development of colorectal cancer, and lead to poor prognosis of patients is an important factor, the paper published online in the May 13 " Nature - Communication. Previously, the ligase disclosed in academia is both zinc finger type, and Smurf1 belongs to a new type of ligase, both of which have different mechanisms of action, and the model represented by Smurf1 is conservative from yeast to mammals Further understand the biological significance and function of ubiquitination modification