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观察碱性成纤维细胞生长因子（ｂＦＧＦ）和转化生长因子β１（ＴＧＦβ１）在人发育骨与软骨中的表达和分布，认识这两种生长因子在人发育骨与软骨中的作用，用组织学、免疫组化及原位杂交技术，对临床经过石蜡包埋的人发育骨与软骨组织进行定位、定性检测。结果显示ＴＧＦβ和ｂＦＧＦ在人发育的骨与软骨细胞中共同表达。作者认为ＴＧＦβ和ｂＦＧＦ协同作用可能在人发育骨与软骨中起重要作用。
To observe the expression and distribution of basic fibroblast growth factor (bFGF) and transforming growth factor-β1 (TGFβ1) in human bone and cartilage, and to understand the roles of these two growth factors in human bone and cartilage development. Immunohistochemistry and in situ hybridization were used to detect the bone and cartilage tissues in clinical paraffin-embedded human development. The results show that TGF [beta] and bFGF are co-expressed in human-developed bone and chondrocytes. The authors believe that the synergistic effect of TGFβ and bFGF may play an important role in the development of bone and cartilage in humans.