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目的:探讨不同极性溶剂处理的黄芪提取液对抗胰岛素致低血糖的作用。方法:选择SD雄性大鼠20只,随机抽取4只大鼠作为正常对照组,余为实验组,再将实验组随机均分为四组,分别用等体积的不同极性溶剂处理的黄芪提取液灌胃给药,正常对照组给予相同体积的生理盐水,连续7天后予腹腔注射胰岛素,每隔15分钟取大鼠尾端血测定血糖,观察90分钟内大鼠血糖变化情况。结果:与正常对照组大鼠相比,实验组中部分大鼠在腹腔注射胰岛素后一定时间内血糖仍能保持平稳。结论:黄芪能够在一定程度上对抗胰岛素所致低血糖,以中等极性及极性有效成分作用较为明显。
Objective: To investigate the effects of different polar solvent-treated astragalus extract on insulin-induced hypoglycemia. Methods: Twenty SD male rats were randomly divided into normal control group and control group. The remaining group was experimental group. The experimental group was randomly divided into four groups. The rats were treated with equal volume of different polar solvents The rats in the normal control group were given the same volume of physiological saline. The rats were intraperitoneally injected with insulin for 7 days. The blood glucose was measured every 15 minutes and the changes of blood glucose in 90 minutes were observed. Results: Compared with the normal control rats, some rats in the experimental group remained stable after a certain period of time after intraperitoneal injection of insulin. Conclusion: Astragalus can to a certain extent, against the hypoglycemia caused by insulin, with the role of moderate polarity and polar active ingredients more obvious.