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本文采用免疫组化、PCR技术,检测30例涎腺肿瘤组织中c-myc、P53、Bcl-2蛋白表达和HPV感染。结果显示:多形性腺瘤中,c-myc和P53阳性率分别为50.0%和25.0%,均低于恶性肿瘤阳性率的75.0%和50.8%,两组存在高度显著性差异(P<0.01);15例多形性腺瘤和3例鳞癌中,HPV6.11均为阴性,HPV16.18阳性反应各1例(1/15和1/3)。提示c-myc表达升高,与上皮细胞增殖速度加快及细胞癌变有关;P53蛋白表达,可为判断细胞分化程度的参考指标;HPV16.18具一定协同致癌作用。Bcl-2能引起细胞过度积聚,故为恶性肿瘤的发病机制之一。
In this paper, immunohistochemistry, PCR technique was used to detect the expression of c-myc, P53, Bcl-2 and HPV in 30 salivary gland tumor tissues. The results showed that the positive rates of c-myc and P53 in pleomorphic adenomas were 50.0% and 25.0%, respectively, which were lower than the positive rates of malignant tumors by 75.0% and 50.8%, respectively (P <0.01). Among 15 cases of pleomorphic adenoma and 3 cases of squamous cell carcinoma, HPV6.11 was negative and HPV16.18 positive was 1 case (1/15 and 1/3) respectively. It suggests that the expression of c-myc is elevated, which is related to the proliferation of epithelial cells and the canceration of cells. The expression of P53 protein may be a reference index to determine the degree of cell differentiation. HPV16.18 has some synergistic carcinogenic effects. Bcl-2 can cause excessive accumulation of cells, it is one of the pathogenesis of malignant tumors.