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目的:探讨足月新生儿脐静脉血瘦素和神经肽 Y 水平及其临床意义。方法:采用放射免疫分析测定100例足月新生儿脐静脉血瘦素和神经肽 Y(NPY)浓度。结果:足月新生儿脐静脉血瘦素水平7.15±3.72ug/L,NPY 水平为112±42.36ng/L;女婴组瘦素水平为9.35±3.51ug/L,NPY为138.29±42.67ng/L,均明显高于男婴组瘦素水平(4.95±2.18ug/L)和 NPY 水平(85.85±40.39ng/L),差异有显著意义(P<0.01)。足月新生儿脐静脉血瘦素与新生儿出生体重、孕妇分娩前身高体重指数(BMI)呈显著正相关关系(r 分别为0.647、0.547,P<0.05);NPY 水平与新生儿体重、孕妇分娩前 BMI 亦呈正相关(r 分别为0.584,0.705,P<0.05)。结论:胎儿组织及胎盘产生的瘦素和 NPY 可能参与了妊娠期胎儿体重增长的调节。
Objective: To investigate the umbilical venous blood leptin and neuropeptide Y levels in term neonates and their clinical significance. Methods: Radioimmunoassay was used to determine umbilical venous blood leptin and neuropeptide Y (NPY) concentrations in 100 full-term neonates. Results: The leptin level of full-term neonates was 7.15 ± 3.72ug / L and the NPY level was 112 ± 42.36ng / L. The leptin level of infants was 9.35 ± 3.51ug / L and the NPY was 138.29 ± 42.67ng / L were significantly higher than those of the boy group (4.95 ± 2.18ug / L) and NPY (85.85 ± 40.39ng / L), the difference was significant (P <0.01). There was a significant positive correlation between umbilical venous blood leptin and newborn birth weight, pregnant women before delivery and body mass index (r = 0.647,0.547, P <0.05, respectively). The level of NPY was positively correlated with body weight, BMI before delivery was also positively correlated (r = 0.584, 0.705, P <0.05, respectively). Conclusion: Leptin and NPY produced by fetal tissue and placenta may be involved in the regulation of fetal weight gain during pregnancy.