论文部分内容阅读
目的探讨肿瘤坏死因子-α(TNF-α)在高血压脑出血(HICH)患者血清中的表达以TNF-α在HICH发病中的作用。方法采用ELISA法检测90例术前HICH患者(HICH组)和30例健康体检者(对照组)血清TNF-α水平。结果 HICH组血清TNF-α均显著高于对照组,相比较差异有统计学意义(t=4.663,P﹤0.05)。患者发病6～12h、12～24h、24～48h、48～72h、﹥72h时间段血清TNF-α水平与对照比较均显著上升,相比较差异有统计学意义(t=3.578,4.965,7.284,5.760,5.026,P﹤0.05)。血清TNF-α水平随着GCS评分的下降而上升,GCS评分与TNF-α浓度呈显著负相关性(r=-0.504,P﹤0.05)。结论 TNF-α在HICH患者血清中呈高表达,TNF-α的异常增高预示HICH病情严重。
Objective To investigate the expression of tumor necrosis factor-α (TNF-α) in the serum of patients with hypertensive intracerebral hemorrhage (HICH) and its role in the pathogenesis of HICH. Methods Serum levels of TNF-α in 90 preoperative HICH patients (HICH group) and 30 healthy controls (control group) were detected by ELISA. Results The serum levels of TNF-α in HICH group were significantly higher than those in control group (t = 4.663, P <0.05). The level of TNF-αin patients with onset of 6 ~ 12h, 12 ~ 24h, 24 ~ 48h, 48 ~ 72h and 72h increased significantly compared with the control group, the difference was statistically significant (t = 3.578,4.965,7.284, 5.760, 5.026, P <0.05). Serum TNF-α level increased with the decline of GCS score, GCS score and TNF-α concentration was significantly negatively correlated (r = -0.504, P <0.05). Conclusion TNF-α is highly expressed in the serum of HICH patients. The abnormal increase of TNF-α indicates the severe HICH.