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目的观察鼠神经生长因子对一氧化碳中毒续发脑病患者神经元特异性烯醇化酶(NSE)、一氧化氮(NO)的影响及治疗效果。方法所有患者于入院后随机分为治疗组(29例)、对照组(27例),治疗组在基础治疗时加用鼠神经生长因子18μg(≥9000AU),肌肉注射,1次/次,30d为1疗程。所有患者在入院时、治疗10d、30d,均应用简明痴呆量表进行评定(MMSE),并检测血浆NSE、NO水平。结果治疗10d时,治疗组NO水平较治疗前上升(P<0.05)。治疗30d,治疗组MMSE评分、NO水平上升,NSE水平下降,与治疗前比较有统计学差异(P<0.01);对照组MMSE评分、NO水平升高较治疗前上升(P<0.01),NSE水平较治疗前无下降(P>0.05),两组间MMSE评分、NSE、NO水平比较差异有统计学意义(P<0.05或P<0.01)。结论鼠神经生长因子可保护一氧化碳中毒续发脑病患者神经元,改善智能。
Objective To observe the effect of nerve growth factor (NGF) on neuron-specific enolase (NSE) and nitric oxide (NO) in patients with carbon monoxide poisoning and subsequent encephalopathy. Methods All patients were randomly divided into treatment group (n = 29) and control group (n = 27) after admission. The treatment group was given basic therapy with 18μg of mouse nerve growth factor (≥9000AU), intramuscular injection, once / For a course of treatment. All patients were admitted to the hospital for 10d, 30d, were assessed using a simple dementia scale (MMSE), and plasma levels of NSE, NO. Results At the 10th day after treatment, the level of NO in the treatment group was significantly higher than that before treatment (P <0.05). After 30 days of treatment, MMSE score, NO level and NSE level in treatment group were significantly lower than those before treatment (P <0.01); MMSE score and NO level in control group were significantly higher than those before treatment (P <0.01) The levels of MMSE, NSE and NO in the two groups were significantly different (P <0.05 or P <0.01). Conclusion NGF can protect the neurons of patients with encephalopathy after carbon monoxide poisoning and improve their intelligence.