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P27是近年发现的一种抑癌基因,是细胞周期蛋白依赖性激酶抑制剂(cyclin-dependent kinase inhibitor,CDKIs)家族成员之一。作为细胞周期负调控因子,P27蛋白具有参与细胞周期调控、诱导凋亡、促进细胞分化等多种生物学功能。许多实体瘤存在着P27基因的缺失、突变和低表达,P27的表达水平与急性白血病的发生、发展、治疗、预后密切相关。P27可应用于急性白血病的靶向治疗,通过提高P27蛋白表达水平可治疗白血病。P27基因DNA甲基化研究尚处于初始阶段,急性白血病P27甲基化与基因表达的关系尚未明确,P27基因甲基化的改变能否作为白血病临床早期诊断及治疗的一个重要靶标,有待于深入探讨。
P27 is a tumor suppressor gene discovered in recent years and is a member of the cyclin-dependent kinase inhibitor (CDKIs) family. As a negative regulator of the cell cycle, P27 protein is involved in many biological functions such as cell cycle regulation, apoptosis induction and cell differentiation. Many solid tumors exist the deletion, mutation and low expression of P27 gene. The expression of P27 is closely related to the occurrence, development, treatment and prognosis of acute leukemia. P27 can be used in the targeted therapy of acute leukemia, which can treat leukemia by increasing the expression of P27 protein. P27 gene DNA methylation research is still in its infancy. The relationship between P27 methylation and gene expression in acute leukemia has not yet been clarified. Whether methylation of P27 gene can be used as an important target for early clinical diagnosis and treatment of leukemia remains to be further studied Discussion.