流行性脑脊髓膜炎(流脑)是一种由脑膜炎双球菌感染引起的急性呼吸道传染病,该病起病急、病情重。近年来我国流脑的发病率明显上升,目前国际上应用的脑膜炎球菌疫苗主要有四价脑膜炎球菌结合疫苗MenACWY-CRM(Menveo)、MenACWY-D(Menactra)和脑膜炎多聚糖疫苗(Menomune)。现就脑膜炎球菌结合疫苗应用的最新指南作一综述。 Epidemic meningococcal meningitis (meningitis) is an acute respiratory infection caused by meningococcal disease, the disease is acute and seriously ill. In recent years, the incidence of meningitis in our country has obviously increased. At present, the meningococcal vaccines mainly used in the world include the meningococcal meningococcal tetravalent conjugate vaccines MenACWY-CRM (Menveo), MenACWY-D (Menactra) and meningitis polysaccharide vaccine Menomune). The latest guidance on the use of meningococcal conjugate vaccines is reviewed.