Collectrin是肾素血管紧张素系统中的孤立成员,是血管紧张素转换酶(angiotensin-converting enzyme,ACE)2的同系物,两者约50%的基因序列一致。不像ACE2,collectrin缺乏催化区,其作为氨基酸转运蛋白的分子伴侣发挥功能。Collectrin在部分肾脏切除和高盐食物喂养的啮齿类动物的肾脏中表达增加,这也提出一个问题,即collectrin对血压升高是否有直接作用。该研究人员发现collectrin缺失会导致 Collectrin is an isolated member of the renin-angiotensin system and is a homologue of angiotensin-converting enzyme (ACE) 2, with approximately 50% of the gene sequences in both. Unlike ACE2, collectrin lacks a catalytic domain and functions as a chaperone for amino acid transporters. The increased expression of Collectrin in the kidneys of partially nephrectomized and salt-fed rodents raises the question of whether collectrin has a direct effect on blood pressure. The researchers found that collectrin deficiency can be caused