巨自噬(以下指自噬)是一个高度保守地自我降解地过程,这个过程通过细胞质的组分,包括:细胞器、蛋白质聚集物以及病原体。它们都是被初始的吞噬泡膜俘获,随后紧接着和自噬小体、溶酶体融合进行降解~([1,2])。细胞的自我吞噬有相当多的降解形式,它们对于细胞浆运载蛋白主要是非选择性的,靶向地自噬行为也选择性地吞噬以及降解特异性的运载蛋白~([3])。线粒体自噬是后者一个典 Giant autophagy (hereinafter autophagy) is a highly conserved process of self-degradation through the cytoplasmic components, including organelles, protein aggregates, and pathogens. They are captured by the initial phagocytic membrane, followed by degradation by autophagosomes and lysosomal fusion (1,2). The self-phagocytosis of cells occurs in quite a number of degradative forms. They are largely non-selective for cytosolic proteins and target autophagic selectively phagocytose and degrade specific transport proteins. [3] Mitochondrial autophagy is a classic example of the latter