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目的探讨溶血磷脂酸、炎性因子检测对早期诊断、预防深静脉血栓的价值。方法对108例下肢深静脉血栓患者(实验组)及同期体检的26例健康人(对照组)进行溶血磷脂酸及炎性因子检测,并对结果进行统计学分析。结果治疗前实验组各期患者LPA、IL-6、TNF-α水平明显高于对照组,治疗3、10 d后LPA水平有所下降,但实验组急性期和亚急性期仍高于对照组(P<0.01);实验组中只有急性期和亚急性期患者IL-10水平高于对照组,急性期患者治疗10 d后IL-10水平又明显增高(P<0.05)。慢性期患者治疗前后IL-10水平无差异。结论检测LPA和炎性因子,可对DVT高危人群早期干预和治疗。
Objective To investigate the value of lysophosphatidic acid and inflammatory cytokines in the early diagnosis and prevention of deep vein thrombosis. Methods Totally 108 patients with deep venous thrombosis of lower extremities (experimental group) and 26 healthy subjects (control group) underwent physical examination for lysophosphatidic acid and inflammatory cytokines, and the results were statistically analyzed. Results Before treatment, the levels of LPA, IL-6 and TNF-α in the experimental group were significantly higher than those in the control group, and LPA levels decreased after 3 and 10 days of treatment. However, the levels of LPA, IL-6 and TNF- (P <0.01). Only IL-10 in acute and sub-acute phase was higher in experimental group than in control group. IL-10 level in acute phase was significantly increased after 10 days of treatment (P <0.05). There was no difference in IL-10 level before and after treatment in patients with chronic phase. Conclusions The detection of LPA and inflammatory cytokines may be used for early intervention and treatment of high risk population of DVT.