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目的:回顾性分析原发腮腺淋巴瘤的临床特点、诊治方法和预后情况。方法:收集本中心2004-01-2013-12原发腮腺淋巴瘤患者共10例。病理亚型为弥漫大B细胞淋巴瘤5例,黏膜相关淋巴组织淋巴瘤3例,滤泡性淋巴瘤2例。应用Kaplan-Meier法计算生存率。应用SPSS10.0统计学软件进行相关因素的统计和分析。结果:10例患者中男女比例为7∶3,中位年龄62岁。患者主要临床表现为腮腺、耳垂下、乳突、颌下无痛性肿块,5例累及左侧腮腺,5例为右侧累及,无患者出现双侧腮腺累及。按照Ann Arbor分期标准Ⅰ期30%(3/10),Ⅱ期20%(2/10)、Ⅲ期10%(1/10)、Ⅳ期40%(4/10);有B症状者30%(3/10)。手术+化疗6例,单纯化疗3例,单纯手术1例,完全缓解率100%。随访终点时间为2014年4月30日,中位随访时间36个月。2例进展,8例病情稳定;1例死亡,9例仍存活,5年累积总生存时间为80%。结论:腮腺淋巴瘤发病率低,病理类型多为B细胞型非霍奇金淋巴瘤,对化疗敏感,总体预后较好。
Objective: To retrospectively analyze the clinical features, diagnosis and treatment methods and prognosis of primary parotid lymphoma. Methods: A total of 10 patients with primary parotid lymphoma from January 2004 to December 2013 were collected. Pathological subtype of diffuse large B cell lymphoma in 5 cases, 3 cases of mucosa-associated lymphoid tissue lymphoma, 2 cases of follicular lymphoma. Survival rates were calculated using the Kaplan-Meier method. Apply SPSS10.0 statistical software for statistics and analysis of relevant factors. Results: The male-female ratio was 7: 3 in 10 patients, with a median age of 62 years. The main clinical manifestations of patients were parotid, earlobe, mastoid, submandibular painless mass, 5 cases involving the left parotid gland, 5 cases involved the right side of the parotid gland involvement. According to Ann Arbor staging criteria, 30% (3/10) of stage Ⅰ, 20% (2/10) of stage Ⅱ, 10% (1/10) of stage Ⅲ and 40% (4/10) of stage Ⅳ; % (3/10). Surgery + chemotherapy in 6 cases, chemotherapy alone in 3 cases, simple surgery in 1 case, complete remission rate of 100%. The follow-up time was April 30, 2014 and the median follow-up time was 36 months. 2 cases progressed and 8 cases were stable. One patient died and 9 patients survived. The 5-year cumulative total survival time was 80%. Conclusion: The incidence of parotid lymphoma is low, and most of the pathological types are B cell type non-Hodgkin's lymphoma, which are sensitive to chemotherapy and have good overall prognosis.