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目的观察老年血脂正常冠心病患者采取不同剂量阿托伐他汀钙进行治疗的临床效果。方法将选取的120例老年血脂正常冠心病患者随机分成A组和B组各60例,A组在内科基础治疗的同时加用阿托伐他汀钙10mg口服;B组在内科基础治疗的同时加用阿托伐他汀钙口服40mg,观察2组治疗效果。结果治疗6个月后,B组各项血清炎性因子水平与治疗前相比明显下降,且低于A组(P<0.05)。2组患者治疗后斑块积分、斑块偏心指数及官腔最大狭窄率与治疗前比较均有所改善,且B组的斑块积分下降程度明显大于A组(P<0.05)。2组患者治疗后TC、TG、LDL-C、HDL-C指标均较治疗前有所改善,且B组TC、LDL-C改善程度明显高于A组(P<0.05)。B组在各项心血管不良事件发生率均明显低于A组,差异均有统计学意义(P<0.05)。结论大剂量阿托伐他汀钙对老年血脂正常冠心病的治疗效果更加显著,可显著提高患者的生存质量,值得临床推广。
Objective To observe the clinical effect of elderly patients with coronary heart disease with different doses of atorvastatin calcium. Methods A total of 120 elderly patients with coronary heart disease were randomly divided into A group and B group, 60 cases in each group. A group was treated with atorvastatin calcium 10 mg at the same time as basic medical treatment. In group B, With atorvastatin calcium oral 40mg, observed two groups of treatment. Results After 6 months of treatment, the levels of serum inflammatory cytokines in group B decreased significantly compared with those before treatment, and were lower than those in group A (P <0.05). The plaque score, plaque eccentricity index and maximum stenosis rate of the two groups were improved after treatment, and the plaque score of group B decreased significantly more than that of group A (P <0.05). The levels of TC, TG, LDL-C and HDL-C in both groups were improved after treatment, and the levels of TC and LDL-C in group B were significantly higher than those in group A (P <0.05). The incidence of cardiovascular adverse events in group B was significantly lower than that in group A, the differences were statistically significant (P <0.05). Conclusion High-dose atorvastatin calcium is more effective in treating elderly patients with normal coronary heart disease, which can significantly improve the quality of life of patients and is worthy of clinical promotion.