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目的探讨结直肠癌同时性肝转移的外科治疗临床疗效。方法收集自2001年2月至2008年2月诊治的86例结直肠癌伴同时性肝转移患者的临床资料,分析同时手术和异时手术患者的临床资料,对比2组患者1、3、5年的生存率。结果 2组肝转移瘤直径、肝转移瘤数目、肝转移瘤分布、术前血清CEA和肝功能Child-Pugh分级等临床资料比较差异无统计学意义(P均>0.05);同时手术组1、3、5年累积生存率为80.3%、39.7%、13.8%;异时手术组患者1、3、5年累积生存率为78.7%、38.9%、14.1%,2组生存率无明显统计学差异(P均>0.05)。结论结直肠癌同时性肝转移的患者,行同时手术与异时手术疗效相似,在条件允许的情况下应行同时手术治疗。
Objective To investigate the clinical efficacy of surgical treatment of concurrent liver metastasis of colorectal cancer. Methods The clinical data of 86 patients with colorectal cancer with concurrent liver metastasis from February 2001 to February 2008 were collected. The clinical data of patients undergoing both simultaneous surgery and surgical operation were analyzed. The data of 1, 3, 5 The annual survival rate. Results There was no significant difference in the diameter of liver metastases, the number of liver metastases, the distribution of liver metastases, the preoperative serum CEA and Child-Pugh liver function classification (P> 0.05) The cumulative survival rates at 3 and 5 years were 80.3%, 39.7% and 13.8% respectively. The cumulative survival rates at 1, 3 and 5 years in patients in operation group were 78.7%, 38.9% and 14.1% respectively. There was no significant difference in survival rates between the two groups (P> 0.05). Conclusions Patients with concurrent liver metastases of colorectal cancer have similar curative effect when performed concurrent surgery and heterotopic surgery. Surgical treatment should be performed under the conditions permitting.