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本文应用抗人T淋巴细胞单克隆抗体OKT系列检测20例扩张型心肌病(DC)外周血T淋巴细胞及其亚群OKT_3、OKT_4及OKT_8,并与15例肥厚型心肌病(HCM)、20例慢性充血性心力衰竭(HF)及20例正常健康人(NC)进行比较。经免疫酶标染色法测定,结果发现:DC组OKT_8阳性细胞百分率较HCM、HF及NC组明显降低(P<0.05),而OKT_4/OKT_8比值高于其他三组(P<0.05)。因此推测,T淋巴细胞亚群异常所致的细胞免疫功能紊乱可能是DC发病的重要因素之一。
In this paper, T lymphocyte subsets OKT_3, OKT_4 and OKT_8 in peripheral blood of 20 patients with dilated cardiomyopathy (DC) were detected by OKT series of anti-human T lymphocyte monoclonal antibody and were compared with 15 cases of hypertrophic cardiomyopathy (HCM), 20 Cases of chronic congestive heart failure (HF) and 20 normal healthy people (NC) were compared. The percentage of OKT_8 positive cells in DC group was significantly lower than that in HCM, HF and NC groups (P <0.05), while the ratio of OKT_4 / OKT_8 was higher than the other three groups (P <0.05). Therefore, it is speculated that abnormal cellular immune function caused by abnormal T lymphocyte subsets may be one of the important factors in the pathogenesis of DC.