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目的 测定口腔颌面部恶性肿瘤患者外血周中NK细胞数目。方法 对19例口腔癌患者及对照组11例正常清晨抽取外周血,用流式细胞仪进行分析,测定NK细胞数目。结果 肿瘤患者外周血中的NK细胞数目明显低于对照组(P<0.01);不同分化程度的恶性肿瘤患者外周血中的NK细胞数目也有显著差异。结论 外周血中的NK细胞与恶性肿瘤的生物学行为有一定的关系,对其检测,对临床具有指导意义。
Objective To determine the number of NK cells in peripheral blood of patients with oral and maxillofacial malignant tumors. Methods Twenty-nine patients with oral cancer and 11 healthy controls were enrolled in this study. Peripheral blood was collected in early morning and analyzed by flow cytometry to determine the number of NK cells. Results The number of NK cells in the peripheral blood of tumor patients was significantly lower than that of the control group (P <0.01). There were also significant differences in the number of NK cells in the peripheral blood of malignant tumor patients with different degrees of differentiation. Conclusion The NK cells in peripheral blood have a certain relationship with the biological behavior of malignant tumor, which is of guiding significance to the detection of NK cells in peripheral blood.