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吡喹酮(Praziquantel;Biltricide;代号为Embay—8440)商品名为Droncit,是由西德怡默克与拜耳两药厂于1975年联合制成的一种新型广谱抗寄生虫药。我国上海,医学科学院寄生虫病研究所,于1977年11月合成。现已由上海第六制药厂和南京制药厂进行批量生产。其化学名是2—环己甲酰—1,3,4,6,7,11b—六氢—2H—吡嗪骈[2,1—a]—异喹啉—4—酮。分子式为C_(19)H_(24)N_2O_2。分子量=312.42。其结构式是:
Praziquantel (Praziquantel; Biltricide; codenamed Embay-8440) is marketed as Droncit, a new broad-spectrum antiparasitic drug made in 1975 by the West German-Merck and Bayer pharmaceutical companies. Shanghai, China, Institute of Parasitic Diseases, Academy of Medical Sciences, in November 1977 synthesis. Now by the Shanghai Sixth Pharmaceutical Factory and Nanjing Pharmaceutical Factory for mass production. Its chemical name is 2-cyclohexyl-1,3,4,6,7,11b-hexahydro-2H-pyrazin [2,1-a] -isoquinolin-4-one. The molecular formula is C_ (19) H_ (24) N_2O_2. Molecular weight = 312.42. Its structure is: