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目的 :探讨α 2b干扰素对慢性丙型肝炎 (丙肝 )患者的治疗效果。方法 :采用国产α 2b干扰素 (30 0MU/d)治疗 ,3个月为一疗程 ,共 2个疗程 ,并设常规治疗组 (VitC、门冬氨酸 )为对照。于疗程结束后分别检测患者PBMC内HCV RNA和血清内HCV RNA、抗 HCV。结果 :α 2b干扰素治疗组 2个疗程后慢性丙肝患者PBMC、血清内HCV RNA和抗 HCV转阴率分别为 4 2 .31%、5 7.6 9%、6 5 .38% ,常规治疗组慢性丙肝患者PBMC、血清内HCV RNA和抗 HCV转阴率分别为 13.6 4 %、2 2 .73%、2 7.2 7%。两组差异均有显著性 (P <0 .0 5～P <0 .0 1)。结论 :α 2b干扰素对血清及PBMC内HCV RNA具有肯定的治疗作用 ,其疗效优于常规治疗组 ,但对PBMC内HCV RNA的疗效似有比抗血清内HCV RNA和抗 HCV疗效弱的趋势
Objective: To investigate the therapeutic effect of α 2b interferon on patients with chronic hepatitis C (hepatitis C). Methods: The domestic α 2b interferon (30 MU / d) treatment, 3 months for a course of treatment, a total of 2 courses, and the conventional treatment group (VitC, aspartate) as a control. At the end of the course of treatment, HCV RNA and HCV RNA in the PBMC of patients were detected, and anti-HCV was detected. Results: The serum levels of HCV RNA and anti-HCV in chronic hepatitis B patients after 2 cycles of interferon α 2b treatment were 42.31%, 59.69% and 65.38%, respectively. Chronic Hepatitis C patients with HCV RNA and HCV anti-HCV negative rate of PBMC were 13.64%, 22.73% and 7.27% respectively. There was significant difference between the two groups (P <0.05 ~ P <0.01). CONCLUSION: Alpha 2b interferon has positive therapeutic effect on HCV RNA in serum and PBMC, and its curative effect is better than that of conventional treatment group. However, the effect on HCV RNA in PBMC seems to be weaker than that of antisera in HCV RNA and anti-HCV